Pepsinogen I/Pepsinogen II rapid test Jun 28, 2022

What is pepsinogen test?

Helicobacter pylori (HP) infection and atrophic gastritis are two lesions closely related to gastric cancer, HP infection is one of the main causes of atrophic gastritis, and atrophic gastritis has been generally considered to be a precancerous lesion of gastric cancer. .In the development process of HP infection→atrophic gastritis→gastric cancer, all are accompanied by changes in pepsinogen (PG), and the latter has become a good diagnostic index for the first three lesions and its important role in the process of treatment and preventive intervention. Monitoring indicators. Utilizing the determination of serum PG, the census for the early diagnosis of gastric cancer and the preventive intervention plan for gastric cancer have been implemented in Japan, Finland, Norway and other countries. The large-scale population census carried out by PG II has increased the early diagnosis rate of gastric cancer to 90%. my country is also one of the countries with high incidence of gastric cancer, and the large-scale census of gastric cancer should be placed in an important position. In view of HP infection, atrophic gastritis and gastric cancer Close relationship, we must understand the changes of PG in HP infection and atrophic gastritis

Whats clinical significance of pepsin detection ?

Objective To study the relationship between the changes of serum pepsinogen (PG)Ⅰ/PGⅡ ratio and different gastric mucosal diseases, so as to provide screening basis for the early diagnosis of gastric cancer. Methods Chemiluminescence microparticle immunoassay was used to determine the serum pepsinogen (PG)Ⅰ/PGⅡ ratio in 145 patients with different gastric mucosal diseases. Serum PGⅠ, PGⅡ contents, and the PGⅠ/PGⅡ ratio were calculated and analyzed statistically. Results Compared with the chronic non-atrophic gastritis group, the PGⅠ/PGⅡ ratio in patients with gastric ulcer and chronic atrophic gastritis decreased (P<0.05). ), the ratio of PGⅠ/PGⅡ in patients with gastric cancer was significantly decreased (P<0.001); there was no significant difference in the ratio of PGⅠ/PGⅡ among the three groups of atrophic gastritis, gastric cancer and gastric ulcer (all P>0.05). Conclusion The ratio of serum PGⅠ/PGⅡ The changes of gastric mucosa are closely related to gastric mucosal lesions, and have important clinical significance for the early screening of precancerous lesions and gastric cancer.