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What is the best time to test AMH (Anti-Mullerian Hormone) ? Jun 20, 2022

Diagnostic kit for Anti-Mullerian Hormone ( Fluorescence Immunochromatographic Assay )

What does an AMH test actually mean? 

 

AMH, able to quickly and reliably examine functions such as sexual function, female genitalia, and the possibilities in which it may develop, as well as the start of the year that is more indicative of the ability of the fetus.AMH is expressed differently in different stages of male and female growth and development, and its biological effects are also different. The most important clinical application based on its pathophysiological changes is to evaluate the ovarian reserve of women, and further assist in the diagnosis of reproductive system-related diseases and other

diseases. In-treatment assessment of female fertility provides the basis.

2. Clinical applications

In terms of evaluating ovarian reserve, anti-Mullerian hormone (AMH) testing can make up for the insufficiency of traditional hormone testing, and can quickly and effectively know the level of ovarian reserve.

 

 

Female fertility is closely related to its ovarian reserve and various reproductive hormones in the body. Insufficient ovarian reserve can lead to premature aging in women, prolonged menstrual cycles, aggravated cardiovascular problems, and even lead to symptoms such as menopause, menopause, and infertility.

Correct evaluation of ovarian reserve is the key to preventing female aging and preventing infertility. AMH detection has the following clinical applications:

In terms of evaluating ovarian reserve, anti-Mullerian hormone (AMH) testing can make up for the insufficiency of traditional hormone testing, and can quickly and effectively know the level of ovarian reserve.Female fertility is closely related to its ovarian reserve and various reproductive hormones in the body. Insufficient ovarian reserve can lead to premature aging in women, prolonged menstrual cycles, aggravated cardiovascular problems, and even lead to symptoms such as menopause, menopause, and infertility.Correct evaluation of ovarian reserve is the key to preventing female aging and preventing infertility. AMH detection has the following clinical applications:

2.1 Assess ovarian reserve

Compared with other traditional biological indicators, AMH has many obvious advantages in evaluating ovarian reserve and is the most accurate biomarker of ovarian aging AMH reflects the trend of ovarian reserve decline with age earlier than FSH, estradiol (E2), inhibinB (inhB) and antral follicle count (AFC)  and its levels are not Influenced by the menstrual cycle, hormonal contraceptives, and pregnancy  Although some studies have shown that there is a certain fluctuation in AMH during the menstrual cycle of women, especially young women, the fluctuation is much smaller than that of other sex hormones. Therefore, the existing guidelines mostly support the detection of AMH at any time in the menstrual cycle. In addition, Fanchin et al. compared the repeatability of AMH and other ovarian reserve markers during different menstrual cycles. AMH is a hormone that satisfies the intra-group correlation coefficient > 0.8, indicating that the variability of AMH between menstrual cycles is also small. Therefore, AMH is one of the most stable and reliable indicators of ovarian reserve.

2.2 Assessing ovarian reserve in cancer patients

Surgery, chemotherapy, and radiotherapy may affect ovarian reserve in cancer patients. A 10-year follow-up study showed that AMH levels in childhood cancer survivors were significantly lower than their healthy peers, and tincreased on average 75-fold in granulosa cells of anovulatory PCOS compared with granulosa cells of normal ovaries. Another study showed that the serum AMH level in women with PCOS was 2-3 times higher than that in women with normal ovulation, and the higher the serum AMH level was, the higher the diagnosis rate of PCOS was. When the AMH level was >10 ng/ml, the diagnosis rate of PCOS was higher. Can reach 97% to 100%. Due to differences in detection methods and test populations, the cut-off value of AMH levels for the diagnosis of PCOS is not uniform, ranging from 2.8 to 8.4 ng/ml.he rate of infertility was increasing. Among breast cancer patients, those with lower preoperative AMH levels were less likely to return to menstruation within one year after surgery. Among patients undergoing ovarian cystectomy, AMH levels were lower in those who used electrocoagulation to stop bleeding than those who used sutures or hemostatic materials. In addition, assessment of serum AMH levels before chemotherapy can be used to predict ovarian function after chemotherapy. A prospective study showed that patients with early-stage breast cancer with lower AMH levels before treatment were more likely to have amenorrhea after chemotherapy. The speed of recovery of AMH levels after chemotherapy in cancer patients is inversely proportional to the ovarian toxicity of chemotherapy drugs. It can be seen that AMH levels can predict ovarian function in cancer patients and help patients who wish to preserve fertility to choose drugs and surgical methods.

2.3. Assisted reproduction

AMH levels can accurately predict a patient's response to controlled ovarian stimulation (COS) and select individualized treatment options accordingly. A Meta study by Broer et al showed that the area under the curve of AMH level for predicting poor ovarian response (POR) was 0.81, which was significantly higher than that of age, basal FSH level and AFC. Ovarian hyperstimulation syndrome (OHSS) is one of the main complications of assisted reproductive ovulation induction techniques, and AMH level can be a good predictor of OHSS. A multicenter prospective study established a cut-point value of 1.1 ng/ml for predicting ovarian hyporesponsiveness and 2.6 ng/ml for predicting ovarian hyperstimulation using AMH levels in a Chinese population.

2.4. Diagnosing Polycystic Ovary Syndrome

 

Compared with healthy ovulating women, the concentration of AMH in the follicular fluid of ovulating polycystic ovary syndrome (PCOS) patients was 5 times higher than normal. Furthermore, AMH production per granulosa cell increased on average 75-fold in granulosa cells of anovulatory PCOS compared with granulosa cells of normal ovaries. Another study showed that the serum AMH level in women with PCOS was 2-3 times higher than that in women with normal ovulation, and the higher the serum AMH level was, the higher the diagnosis rate of PCOS was. When the AMH level was >10 ng/ml, the diagnosis rate of PCOS was higher. Can reach 97% to 100%. Due to differences in detection methods and test populations, the cut-off value of AMH levels for the diagnosis of PCOS is not uniform, ranging from 2.8 to 8.4 ng/ml.

2.5. Predicting menopause and diagnosing premature ovarian failure

2.6.Other clinical applications

 

AMH has been proved to be a specific circulating index of granulosa cell tumors, and its diagnostic sensitivity is 76% to 93% [37]; and serum AMH level is proportional to the size of ovarian granulosa cell tumors, which is directly related to the results of imaging Correlation. AMH can also indicate the recurrence of granulosa cell tumor 11 months earlier than other clinical indicators.

3.What is the best time to test AMH?

Blood specimen and can be test at any time.

 

 

The Related products are available:

Diagnostic kit for progesterone (Prog)

Diagnostic kit for Folicle-Stimulating Hormone ( FSH)

Diagnostic kit for Luteinizing Hormone (LH)

 

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