CA 125 test (cancer antigen 125 or carbohydrate antigen 125) measures the amount of the MUC16 protein in the blood, which acts as a tumor marker to help monitor specific cancers and evaluate pelvic symptoms.
What the Test is Used For
• Monitoring Treatment: Tracking how well treatment (such as chemotherapy or surgery) is working for diagnosed ovarian, fallopian tube, or peritoneal cancers—falling levels generally indicate a good response.
• Checking for Recurrence: Watching for rising levels after treatment finishes to see if cancer has returned.
• Evaluating Pelvic Symptoms: Helping doctors assess unusual pelvic masses, cysts, or symptoms in combination with imaging like an ultrasound.
• High-Risk Screening: Recommended only for individuals at very high risk of ovarian cancer (such as those with strong family histories or specific inherited gene mutations like BRCA), often paired with a transvaginal ultrasound.
Normal and Elevated Ranges
• Normal Range: Typically 0 to 35 units/mL (U/mL), though exact cutoffs can vary slightly depending on the laboratory.
• Elevated Levels (>35 U/mL): Does not automatically mean you have cancer. The CA 125 test has a high rate of false positives because many common, non-cancerous conditions can raise the number.
Which cancers raise CA-125?
A high CA-125 (cancer antigen 125) blood level is most commonly linked to ovarian cancer, though it can also be raised by several other gynecological, non-gynecological, and benign conditions.
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Post time: Nov-05-2026